Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma.

Essers, Paul B M; van der Heijden, Martijn; Vossen, David; de Roest, Reinout H; Leemans, C René; Brakenhoff, Ruud H; van den Brekel, Michiel W M; Bartelink, Harry; Verheij, Marcel; Vens, Conchita

Essers, Paul B M; van der Heijden, Martijn; Vossen, David; de Roest, Reinout H; Leemans, C René; Brakenhoff, Ruud H; van den Brekel, Michiel W M; Bartelink, Harry; Verheij, Marcel; Vens, Conchita.

Affiliation

Essers PBM; Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
van der Heijden M; Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Vossen D; Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
de Roest RH; Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Leemans CR; Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands.
Brakenhoff RH; Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands.
van den Brekel MWM; Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Cancer Center Amsterdam, The Netherlands.
Bartelink H; Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Verheij M; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Vens C; Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Int J Cancer ; 147(6): 1732-1739, 2020 09 15.

Article in En | MEDLINE | ID: mdl-32167160

Subject(s)

Biomarkers, Tumor/genetics; Chemoradiotherapy; Head and Neck Neoplasms/therapy; Ovarian Neoplasms/genetics; Squamous Cell Carcinoma of Head and Neck/therapy; Adult; Aged; Aged, 80 and over; Biopsy; Cisplatin/pharmacology; Cisplatin/therapeutic use; DNA Copy Number Variations; Datasets as Topic; Drug Resistance, Neoplasm/genetics; Female; Follow-Up Studies; Gene Expression Profiling; Head and Neck Neoplasms/genetics; Head and Neck Neoplasms/mortality; Head and Neck Neoplasms/pathology; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Netherlands/epidemiology; Prognosis; Progression-Free Survival; RNA-Seq; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck/genetics; Squamous Cell Carcinoma of Head and Neck/mortality; Squamous Cell Carcinoma of Head and Neck/pathology; Transcriptome/genetics; Whole Genome Sequencing

Key words

HNSCC; chemoradiotherapy; cisplatin; copy number alterations; head and neck squamous cell carcinoma; prognosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Biomarkers, Tumor / Chemoradiotherapy / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Int J Cancer Year: 2020 Document type: Article Affiliation country: Netherlands

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