Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions.

Kwon, Min-Young; Hwang, Narae; Back, Sung Hoon; Lee, Seon-Jin; Perrella, Mark A; Chung, Su Wol

Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions.

Kwon, Min-Young; Hwang, Narae; Back, Sung Hoon; Lee, Seon-Jin; Perrella, Mark A; Chung, Su Wol.

Affiliation

Kwon MY; Laboratory of Molecular Immunology, Department of Biological Sciences, University of Ulsan, South Korea.
Hwang N; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Back SH; Laboratory of Molecular Immunology, Department of Biological Sciences, University of Ulsan, South Korea.
Lee SJ; Laboratory of Molecular Immunology, Department of Biological Sciences, University of Ulsan, South Korea.
Perrella MA; Environmental Disease Research Center, KRIBB, Daejeon, Korea.
Chung SW; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

FEBS J ; 287(10): 2055-2069, 2020 05.

Article in En | MEDLINE | ID: mdl-32167239

Subject(s)

Activating Transcription Factor 6/genetics; Atherosclerosis/genetics; Nod2 Signaling Adaptor Protein/genetics; Transcription Factor CHOP/genetics; Animals; Apolipoproteins E/genetics; Apoptosis/genetics; Atherosclerosis/pathology; Cell Death/genetics; Disease Models, Animal; Endoplasmic Reticulum/genetics; Endoplasmic Reticulum Stress/genetics; Humans; Mice; Mice, Knockout; Muscle, Smooth, Vascular/metabolism; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/metabolism; Myocytes, Smooth Muscle/pathology

Key words

ATF6; CHOP; ER stress; NOD2; cell death

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Activating Transcription Factor 6 / Transcription Factor CHOP / Nod2 Signaling Adaptor Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2020 Document type: Article Affiliation country: South Korea Country of publication: United kingdom

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