Factors associated with psoriasis in a French Nationwide HIV cohort: the independent role of HLA-B*57:01.
AIDS
; 34(7): 1057-1063, 2020 06 01.
Article
in En
| MEDLINE
| ID: mdl-32167971
ABSTRACT
OBJECTIVE:
Psoriasis is a T-cell-mediated inflammatory disease with genetic factors involved in its etiopathogenesis. In non-HIV populations, HLA-B5701 has been associated with a higher risk of psoriasis. The aim of this study was to investigate demographic and immunovirological characteristics associated with psoriasis, and to assess whether HLA-B5701 is associated with psoriasis among people living with HIV (PLHIV) followed in a large French multicenter Dat'AIDS cohort.METHODS:
All PLHIV followed up from January 2000 to December 2018 with an available result for HLA-B5701 were included. Logistic regression models were used to identify associations between psoriasis (outcome variable) and explanatory variables.RESULTS:
Among 31â076 PLHIV, the overall prevalence of psoriasis and HLA-B5701 were 2.25 and 4.73%, respectively and varied according to ethnicity. By multivariate analysis, male gender [OR 1.81 (95% CI 1.46-2.24), Pâ<â10], positive HLA-B5701 [OR 2.66 (95% CI 2.12-3.33), Pâ<â10], nadir CD4 cell count less than 200 cells/µl [OR 1.41 (95% CI 1.19-1.67), Pâ<â10] and positive HCV serology [OR 1.45 (95% CI 1.20-1.76), Pâ<â10] were significantly associated with a higher risk of psoriasis. Being born in West and Central Africa [OR 0.15 (95% CI 0.10-0.25), Pâ<â10], the Caribbean islands [OR 0.14 (95% CI 0.05-0.45), Pâ=â0.0008] or Latin America [OR 0.31 (95% CI 0.14-0.69), Pâ=â0.004] was associated with a lower risk of psoriasis compared with patients born in mainland France.CONCLUSION:
PLHIV carrying HLA-B5701 have around a three-fold increased risk of psoriasis. This association might provide a possible explanation for the observed differences in psoriasis prevalence between ethnic groups.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psoriasis
/
HLA-B Antigens
/
HIV Infections
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2020
Document type:
Article