Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults.
Nutrients
; 12(3)2020 Mar 12.
Article
in En
| MEDLINE
| ID: mdl-32178279
ABSTRACT
BACKGROUND:
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios.AIMS:
We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism.METHODS:
In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day of EPA-rich (EPA/DHA 2.3) or DHA-rich (EPA/DHA 0.3) fish oil for 8-weeks, separated by an 8-week washout period.RESULTS:
Both fish oil supplements similarly lowered plasma TG levels and TG-related NMR parameters versus baseline (p < 0.05). There were no changes in plasma cholesterol-related parameters due to either fish oil, although on-treatment levels for LDL particle number were slightly higher for DHA-rich oil compared with EPA-rich oil (p < 0.05). Both fish oil supplements similarly altered HDL subclass profile and proteome, and down regulated HDL proteins related to inflammation, with EPA-rich oil to a greater extent. Furthermore, EPA-rich oil increased apoM abundance versus DHA-rich oil (p < 0.05).CONCLUSIONS:
Overall, fish oil supplements with varied EPA/DHA ratios had similar effects on total lipids/lipoproteins, but differences were observed in lipoprotein subfraction composition and distribution, which could impact on the use of EPA versus DHA for improving cardiovascular health.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triglycerides
/
Eicosapentaenoic Acid
/
Docosahexaenoic Acids
/
Lipoproteins, HDL
/
Lipoproteins, LDL
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Nutrients
Year:
2020
Document type:
Article
Affiliation country:
United States