Expanding the Diversity of Plant Monoterpenoid Indole Alkaloids Employing Human Cytochrome P450 3A4.

Sheludko, Yuriy V; Volk, Jascha; Brandt, Wolfgang; Warzecha, Heribert

Sheludko, Yuriy V; Volk, Jascha; Brandt, Wolfgang; Warzecha, Heribert.

Affiliation

Sheludko YV; Plant Biotechnology and Metabolic Engineering, Technische Universität Darmstadt, Schnittspahnstraße 3-5, 64285, Darmstadt, Germany.
Volk J; Plant Biotechnology and Metabolic Engineering, Technische Universität Darmstadt, Schnittspahnstraße 3-5, 64285, Darmstadt, Germany.
Brandt W; Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle/Saale, Germany.
Warzecha H; Plant Biotechnology and Metabolic Engineering, Technische Universität Darmstadt, Schnittspahnstraße 3-5, 64285, Darmstadt, Germany.

Chembiochem ; 21(14): 1976-1980, 2020 07 16.

Article in En | MEDLINE | ID: mdl-32181956

Subject(s)

Cytochrome P-450 CYP3A/metabolism; Rauwolfia/chemistry; Secologanin Tryptamine Alkaloids/metabolism; Epoxy Compounds/chemistry; Epoxy Compounds/metabolism; Humans; Indole Alkaloids/chemistry; Indole Alkaloids/metabolism; Models, Molecular; Molecular Conformation; Rauwolfia/metabolism; Secologanin Tryptamine Alkaloids/chemistry; Stereoisomerism; Substrate Specificity

Key words

CYP3A4; cytochromes; monoterpenoid indole alkaloids; natural products; vinorine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rauwolfia / Secologanin Tryptamine Alkaloids / Cytochrome P-450 CYP3A Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2020 Document type: Article Affiliation country: Germany

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