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EP4 activation ameliorates liver ischemia/reperfusion injury via ERK1/2­GSK3ß­dependent MPTP inhibition.
Cai, Lin-Lin; Xu, Hai-Tao; Wang, Qi-Long; Zhang, Ya-Qing; Chen, Wei; Zheng, Dong-Yu; Liu, Fang; Yuan, Hong-Bin; Li, Yong-Hua; Fu, Hai-Long.
Affiliation
  • Cai LL; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Xu HT; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Wang QL; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Zhang YQ; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Chen W; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Zheng DY; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Liu F; National Key Laboratory of Medical Immunology and Department of Immunology, Second Military Medical University, Shanghai 200433, P.R. China.
  • Yuan HB; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Li YH; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
  • Fu HL; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
Int J Mol Med ; 45(6): 1825-1837, 2020 Jun.
Article in En | MEDLINE | ID: mdl-32186754
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury / MAP Kinase Signaling System / Mitochondrial Membrane Transport Proteins / Receptors, Prostaglandin E, EP4 Subtype / Glycogen Synthase Kinase 3 beta / Mitochondrial Permeability Transition Pore / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2020 Document type: Article Country of publication: Greece
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury / MAP Kinase Signaling System / Mitochondrial Membrane Transport Proteins / Receptors, Prostaglandin E, EP4 Subtype / Glycogen Synthase Kinase 3 beta / Mitochondrial Permeability Transition Pore / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2020 Document type: Article Country of publication: Greece