Your browser doesn't support javascript.
loading
BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing.
Rinonce, Hanggoro Tri; Aji, Rovi Panji Mustiko; Hayati, Ni'mah; Pudjohartono, Maria Fransiska; Kameswari, Bidari; Anwar, Sumadi Lukman.
Affiliation
  • Rinonce HT; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Sleman, Yogyakarta, 55281, Indonesia. hanggoro_rinonce@ugm.ac.id.
  • Aji RPM; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Sleman, Yogyakarta, 55281, Indonesia.
  • Hayati N; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Sleman, Yogyakarta, 55281, Indonesia.
  • Pudjohartono MF; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Sleman, Yogyakarta, 55281, Indonesia.
  • Kameswari B; Department of Anatomical Pathology, dr. Soeradji Tirtonegoro Hospital, Klaten, Central Java, 57424, Indonesia.
  • Anwar SL; Department of Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Sleman, Yogyakarta, 55281, Indonesia.
  • Irianiwati; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Sleman, Yogyakarta, 55281, Indonesia.
BMC Res Notes ; 13(1): 164, 2020 Mar 18.
Article in En | MEDLINE | ID: mdl-32188503
ABSTRACT

OBJECTIVE:

We aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia using pyrosequencing.

RESULTS:

BRAF V600 mutations of the V600E type were found in 21 (53.85%) specimens. The variant allele frequencies (VAFs) ranged from 5.07 to 94.70%, averaging 29.05%. However, most cases had low VAFs, with 13 (61.9%) specimens below 20% and 4 (19.05%) below 10%.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Proto-Oncogene Proteins B-raf / Melanoma Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: BMC Res Notes Year: 2020 Document type: Article Affiliation country: Indonesia Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Proto-Oncogene Proteins B-raf / Melanoma Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: BMC Res Notes Year: 2020 Document type: Article Affiliation country: Indonesia Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM