Your browser doesn't support javascript.
loading
FAM13A affects body fat distribution and adipocyte function.
Fathzadeh, Mohsen; Li, Jiehan; Rao, Abhiram; Cook, Naomi; Chennamsetty, Indumathi; Seldin, Marcus; Zhou, Xiang; Sangwung, Panjamaporn; Gloudemans, Michael J; Keller, Mark; Attie, Allan; Yang, Jing; Wabitsch, Martin; Carcamo-Orive, Ivan; Tada, Yuko; Lusis, Aldons J; Shin, Myung Kyun; Molony, Cliona M; McLaughlin, Tracey; Reaven, Gerald; Montgomery, Stephen B; Reilly, Dermot; Quertermous, Thomas; Ingelsson, Erik; Knowles, Joshua W.
Affiliation
  • Fathzadeh M; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Li J; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Rao A; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
  • Cook N; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Chennamsetty I; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Seldin M; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
  • Zhou X; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Sangwung P; Bioengineering Department, School of Engineering and Medicine, Stanford, CA, USA.
  • Gloudemans MJ; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Keller M; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Attie A; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Yang J; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Wabitsch M; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Carcamo-Orive I; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Tada Y; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Lusis AJ; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Shin MK; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
  • Molony CM; Department of Genetics, Stanford University, California, CA, USA.
  • McLaughlin T; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.
  • Reaven G; Department of Biochemistry, University of Wisconsin, Madison, WI, USA.
  • Montgomery SB; Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Reilly D; Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.
  • Quertermous T; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Ingelsson E; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
  • Knowles JW; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
Nat Commun ; 11(1): 1465, 2020 03 19.
Article in En | MEDLINE | ID: mdl-32193374
ABSTRACT
Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipocytes / GTPase-Activating Proteins / Body Fat Distribution Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipocytes / GTPase-Activating Proteins / Body Fat Distribution Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: United States