Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora.
Nat Prod Res
; 35(23): 5229-5232, 2021 Dec.
Article
in En
| MEDLINE
| ID: mdl-32202440
ABSTRACT
Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC90 value of 51.2 µM and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC50 values of 2.3 and 18.3 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uvaria
Limits:
Humans
Language:
En
Journal:
Nat Prod Res
Year:
2021
Document type:
Article
Affiliation country:
Philippines