Antitumor activity of gemcitabine hydrochloride loaded lipid polymer hybrid nanoparticles (LPHNs): In vitro and in vivo.

Yalcin, Tahir Emre; Ilbasmis-Tamer, Sibel; Takka, Sevgi

Yalcin, Tahir Emre; Ilbasmis-Tamer, Sibel; Takka, Sevgi.

Affiliation

Yalcin TE; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06330 Etiler, Ankara, Turkey.
Ilbasmis-Tamer S; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06330 Etiler, Ankara, Turkey.
Takka S; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06330 Etiler, Ankara, Turkey. Electronic address: takka@gazi.edu.tr.

Int J Pharm ; 580: 119246, 2020 Apr 30.

Article in En | MEDLINE | ID: mdl-32205141

Subject(s)

Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Deoxycytidine/analogs & derivatives; Lipids/chemistry; Nanoparticles/chemistry; Polymers/chemistry; Animals; Antimetabolites, Antineoplastic/chemistry; Carcinoma, Non-Small-Cell Lung/drug therapy; Cell Line, Tumor; Deoxycytidine/chemistry; Deoxycytidine/pharmacology; Drug Delivery Systems/methods; Drug Liberation/drug effects; Humans; Lung Neoplasms/drug therapy; MCF-7 Cells; Pancreatic Neoplasms/drug therapy; Particle Size; Rats; Rats, Sprague-Dawley; Gemcitabine; Pancreatic Neoplasms

Key words

Anti-tumor activity; Cytotoxicity; Gemcitabine hydrochloride; Lipid polymer hybrid nanoparticles; Pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / Deoxycytidine / Nanoparticles / Lipids / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Int J Pharm Year: 2020 Document type: Article Affiliation country: Turkey Country of publication: Netherlands

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