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A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques.
Van Rompay, Koen K A; Coffey, Lark L; Kapoor, Tania; Gazumyan, Anna; Keesler, Rebekah I; Jurado, Andrea; Peace, Avery; Agudelo, Marianna; Watanabe, Jennifer; Usachenko, Jodie; Singapuri, Anil; Immareddy, Ramya; Ardeshir, Amir; Stuart, Jackson B; Bournazos, Stylianos; Ravetch, Jeffrey V; Balderes, Paul J; Lorenz, Ivo C; Esswein, Shannon R; Keeffe, Jennifer R; Bjorkman, Pamela J; Wang, Qiao; Rice, Charles M; MacDonald, Margaret R; Nussenzweig, Michel C; Robbiani, Davide F.
Affiliation
  • Van Rompay KKA; California National Primate Research Center, University of California, Davis, CA 95616; kkvanrompay@ucdavis.edu nussen@rockefeller.edu drobbiani@rockefeller.edu.
  • Coffey LL; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Kapoor T; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065.
  • Keesler RI; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065.
  • Jurado A; California National Primate Research Center, University of California, Davis, CA 95616.
  • Peace A; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
  • Agudelo M; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
  • Watanabe J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065.
  • Usachenko J; California National Primate Research Center, University of California, Davis, CA 95616.
  • Singapuri A; California National Primate Research Center, University of California, Davis, CA 95616.
  • Immareddy R; California National Primate Research Center, University of California, Davis, CA 95616.
  • Ardeshir A; California National Primate Research Center, University of California, Davis, CA 95616.
  • Stuart JB; California National Primate Research Center, University of California, Davis, CA 95616.
  • Bournazos S; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616.
  • Ravetch JV; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065.
  • Balderes PJ; Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10065.
  • Lorenz IC; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
  • Esswein SR; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065.
  • Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
  • Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
  • Wang Q; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
  • Rice CM; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065.
  • MacDonald MR; Key Laboratory of Medical Molecular Virology of Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, 200032 Shanghai, China.
  • Nussenzweig MC; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
  • Robbiani DF; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
Proc Natl Acad Sci U S A ; 117(14): 7981-7989, 2020 04 07.
Article in En | MEDLINE | ID: mdl-32209664
ABSTRACT
Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive immunization can protect nonhuman primates and their fetuses during pregnancy has not been determined. Z004 and Z021 are neutralizing monoclonal antibodies to domain III of the envelope (EDIII) of ZIKV. Together the two antibodies protect nonpregnant macaques against infection even after Fc modifications to prevent antibody-dependent enhancement (ADE) in vitro and extend their half-lives. Here we report on prophylactic coadministration of the Fc-modified antibodies to pregnant rhesus macaques challenged three times with ZIKV during first and second trimester. The two antibodies did not entirely eliminate maternal viremia but limited vertical transmission, protecting the fetus from neurologic damage. Thus, maternal passive immunization with two antibodies to EDIII can shield primate fetuses from the harmful effects of ZIKV.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Infectious Disease Transmission, Vertical / Zika Virus / Zika Virus Infection / Antibodies, Monoclonal Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Infectious Disease Transmission, Vertical / Zika Virus / Zika Virus Infection / Antibodies, Monoclonal Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article