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Haemophilus influenzae type b invasive infections in children hospitalized between 2000 and 2017 in a Pediatric Reference Hospital (PRH).
Delfino Sosa, Marcos; Zabala, Cristina; Pardo, Lorena; Fernández, Lucía; Nieves, Cecilia; Más, Mariana; Barrios, Patricia; Algorta, Gabriela; Mota, María Inés; Varela, Adriana; Gutiérrez, Claudia; Gutiérrez, Stella; Giachetto, Gustavo; Pírez, María Catalina.
Affiliation
  • Delfino Sosa M; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Zabala C; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Pardo L; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Fernández L; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Nieves C; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Más M; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Barrios P; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Algorta G; Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell. Facultad de Medicina, Universidad de la República, Uruguay.
  • Mota MI; Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell. Facultad de Medicina, Universidad de la República, Uruguay.
  • Varela A; Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell. Facultad de Medicina, Universidad de la República, Uruguay.
  • Gutiérrez C; Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell. Facultad de Medicina, Universidad de la República, Uruguay.
  • Gutiérrez S; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Giachetto G; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
  • Pírez MC; Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.
Heliyon ; 6(3): e03483, 2020 Mar.
Article in En | MEDLINE | ID: mdl-32215324
ABSTRACT

BACKGROUND:

Uruguay incorporated the conjugate vaccine against Haemophilus influenzae b (Hib) in 1994. In 2008, the vaccine was changed from one with natural conjugated capsular polysaccharide to one with a synthetic polysaccharide component. We describe the frequency and characteristics of invasive Hib infections in children hospitalized in a Pediatric Reference Hospital (PRH) between January 1st, 2000 and December 31st, 2017.

METHODS:

Sterile site Hib isolations from hospitalized children were included. Clinical and microbiological characteristics were analyzed. Favorable conditions for the infection were considered incomplete immunization, immunodeficiencies and associated pathologies. Two periods are described 1, prior to vaccine change (1/1 st/2000- 12/31/08) and 2, post-change (1/1 st/09- 12/31st/17).

RESULTS:

45 children were hospitalized 5 in the first period and 40 in the second. The hospitalization rate per 10,000 discharges was 0.41 (95% CI 0.05-0.77) and 4.2/10,000 (95% CI 2.89-5.48), respectively (p < 0.01). The diagnoses at discharge were meningitis/ventriculitis (20), pneumonia (16), bacteremia (3), epiglottitis (1), arthritis (1), cellulitis (3) and obstruction of the upper airway (1). Four children presented comorbidities. Twenty seven received less than 3 doses of anti-Hib vaccination and 18 were properly vaccinated (2 were immunodeficient). The median hospitalization was 14 days, 18 children required intensive therapy.

CONCLUSIONS:

Observed change may be due to incomplete primary series, inhomogeneous vaccine coverage and immunogenicity of the synthetic polysaccharide. To reduce this public health problem, epidemiological surveillance.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Heliyon Year: 2020 Document type: Article Affiliation country: Uruguay

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Heliyon Year: 2020 Document type: Article Affiliation country: Uruguay