Factors associated with severity of adverse events following yellow fever vaccination during the biggest outbreak of the disease recorded in Brazil, 2016-2017. / Fatores associados à gravidade dos eventos adversos pós-vacinação contra a febre amarela durante o maior surto da doença registrado no Brasil, 2016-2017.
Epidemiol Serv Saude
; 29(1): e2018331, 2020.
Article
in En, Pt
| MEDLINE
| ID: mdl-32215531
ABSTRACT
OBJECTIVE:
to analyze characteristics, incidence and factors associated with serious adverse events (SAEs) following yellow fever vaccination during an outbreak of the disease in Brazil (2016-2017).METHODS:
this was a case-control study using data from the National Immunization Program Information System (SI-PNI); SAE were considered to be cases, and non-serious adverse events (NSAE) were considered to be controls.RESULTS:
we analyzed 135 SAE cases and 1,058 controls; of the 135 SAE, 79 (58.5%) were males and median age was 28 years [09-49]; incidence in January 2017 reached 1.3 case per 100,000 vaccine doses administered; there was statistical association with males (Odds Ratio [OR]=1.73 - 95%CI 1.20;2.48), primary vaccination (OR=1.65 - 95%CI 1.01;2.71), and being 60 years of age or older taking as reference those aged under 5 (OR=4.4; p-value <0.02).CONCLUSION:
SAE owing to yellow fever vaccine showed a greater chance of occurring in men, the elderly and primary vaccination.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Yellow Fever
/
Disease Outbreaks
/
Vaccination
/
Yellow Fever Vaccine
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Brasil
Language:
En
/
Pt
Journal:
Epidemiol Serv Saude
Year:
2020
Document type:
Article
Affiliation country:
Brazil