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Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Tian, Lian; Wu, Danchen; Dasgupta, Asish; Chen, Kuang-Hueih; Mewburn, Jeffrey; Potus, Francois; Lima, Patricia D A; Hong, Zhigang; Zhao, Yuan-Yuan; Hindmarch, Charles C T; Kutty, Shelby; Provencher, Steeve; Bonnet, Sebastien; Sutendra, Gopinath; Archer, Stephen L.
Affiliation
  • Tian L; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Wu D; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Dasgupta A; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Chen KH; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Mewburn J; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Potus F; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Lima PDA; Queen'ps CardioPulmonary Unit, Department of Medicine, Translational Institute of Medicine (P.D.A.L., C.C.T.H., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Hong Z; Department of Pharmacology, University of Illinois at Chicago (Z.H.).
  • Zhao YY; Department of Agricultural, Food and Nutritional Science (Y.-Y.Z.), University of Alberta, Edmonton, Canada.
  • Hindmarch CCT; Queen'ps CardioPulmonary Unit, Department of Medicine, Translational Institute of Medicine (P.D.A.L., C.C.T.H., S.L.A.), Queen's University, Kingston, Ontario, Canada.
  • Kutty S; Department of Medicine, John Hopkins University, Baltimore, MD (S.K.).
  • Provencher S; Pulmonary Hypertension Research Group, Department of Medicine, Heart and Lung Institute of Quebec, Laval University, Canada (S.P., S.B.).
  • Bonnet S; Pulmonary Hypertension Research Group, Department of Medicine, Heart and Lung Institute of Quebec, Laval University, Canada (S.P., S.B.).
  • Sutendra G; Department of Medicine (G.S.), University of Alberta, Edmonton, Canada.
  • Archer SL; From the Department of Medicine (L.T., D.W., A.D., K.-H.C., J.M., F.P., S.L.A.), Queen's University, Kingston, Ontario, Canada.
Circ Res ; 126(12): 1723-1745, 2020 06 05.
Article in En | MEDLINE | ID: mdl-32216531
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epigenesis, Genetic / Myofibroblasts / Pyruvate Dehydrogenase Acetyl-Transferring Kinase / Heart Ventricles / Hypertension, Pulmonary / Mitochondria, Heart Type of study: Etiology_studies Limits: Animals Language: En Journal: Circ Res Year: 2020 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epigenesis, Genetic / Myofibroblasts / Pyruvate Dehydrogenase Acetyl-Transferring Kinase / Heart Ventricles / Hypertension, Pulmonary / Mitochondria, Heart Type of study: Etiology_studies Limits: Animals Language: En Journal: Circ Res Year: 2020 Document type: Article Affiliation country: Canada