A remarkable in vitro cytotoxic, cell cycle arresting and proapoptotic characteristics of low-dose mixed micellar simvastatin combined with alendronate sodium.

Bandgar, Sandip A; Jadhav, Namdeo R; Manjappa, Arehalli S

Bandgar, Sandip A; Jadhav, Namdeo R; Manjappa, Arehalli S.

Affiliation

Bandgar SA; Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, 416112, India.
Jadhav NR; Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013, India.
Manjappa AS; Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013, India. nrjadhav18@rediffmail.com.

Drug Deliv Transl Res ; 10(4): 1122-1135, 2020 08.

Article in En | MEDLINE | ID: mdl-32221848

Subject(s)

Alendronate/administration & dosage; Antineoplastic Agents/administration & dosage; Simvastatin/administration & dosage; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Humans; Micelles; Poloxamer/administration & dosage

Key words

Bisphosphonate; Cell cycle arresting and apoptosis; Cytotoxicity; Mixed micelles; Simvastatin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alendronate / Simvastatin / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Drug Deliv Transl Res Year: 2020 Document type: Article Affiliation country: India Country of publication: United States

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