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Dyslipidemia in pediatric CKD patients: results from KNOW-PedCKD (KoreaN cohort study for Outcomes in patients With Pediatric CKD).
Baek, Hee Sun; Kim, Seong Heon; Kang, Hee Gyung; Choi, Hyun Jin; Cheong, Hae Il; Ha, Il Soo; Han, Kyoung Hee; Cho, Hee Yeon; Shin, Jae Il; Park, Young Seo; Lee, Joo Hoon; Ahn, Yo Han; Park, Eujin; Cho, Min Hyun.
Affiliation
  • Baek HS; Department of Pediatrics, Kyungpook National University, School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea.
  • Kim SH; Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Republic of Korea.
  • Kang HG; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
  • Choi HJ; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
  • Cheong HI; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
  • Ha IS; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea.
  • Han KH; Department of Pediatrics, Jeju University Hospital, Jeju, Republic of Korea.
  • Cho HY; Department of Pediatrics, Samsung Medical Center, Seoul, Republic of Korea.
  • Shin JI; Department of Pediatrics, Severance Children's Hospital, Seoul, Republic of Korea.
  • Park YS; Department of Pediatrics, Asan Medical Center, Seoul, Republic of Korea.
  • Lee JH; Department of Pediatrics, Asan Medical Center, Seoul, Republic of Korea.
  • Ahn YH; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Park E; Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea.
  • Cho MH; Department of Pediatrics, Kyungpook National University, School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea. chomh@knu.ac.kr.
Pediatr Nephrol ; 35(8): 1455-1461, 2020 08.
Article in En | MEDLINE | ID: mdl-32232640
BACKGROUND: Pediatric as well as adult patients with chronic kidney disease (CKD) are susceptible to cardiovascular disease (CVD) events, which increase their mortality. Dyslipidemia is thought to be one of the most important contributing risk factors for developing CVD. This study aimed to evaluate the prevalence of dyslipidemia and assess clinical and laboratory risk factors associated with dyslipidemia in East Asian pediatric patients with CKD. METHODS: From April 2011 to April 2016, 469 patients with CKD aged < 20 years were enrolled in KNOW-PedCKD (the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease); 356 patients were included in the final analysis. Using the baseline data of the cohort cross-sectionally, a multivariable logistic regression analysis was performed to assess the risk factors for dyslipidemia; a subanalysis for each lipid abnormality was also done. RESULTS: The prevalence of dyslipidemia was 61.5% (n = 219). For dyslipidemia, nephrotic range proteinuria and 25-hydroxyvitamin D deficiency significantly increased the adjusted odds ratio. In the subanalysis, glomerulonephropathy as the origin of CKD and nephrotic range proteinuria significantly increased the risks for high total cholesterol and high low-density lipoprotein cholesterol. Overweight or obese body mass index z-score, elevated proteinuria, hypocalcemia, and 1,25-dihydroxyvitamin D deficiency were significantly associated with low high-density lipoprotein cholesterol. Glomerular filtration rate stage 3b or higher and hyperphosphatemia significantly increased the risk for high triglycerides. CONCLUSIONS: Long-term data accumulation and prospective analysis are needed to clarify the relationship between CKD progression and dyslipidemia and to find additional risk factors for dyslipidemia.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Dyslipidemias Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Pediatr Nephrol Journal subject: NEFROLOGIA / PEDIATRIA Year: 2020 Document type: Article Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Dyslipidemias Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Pediatr Nephrol Journal subject: NEFROLOGIA / PEDIATRIA Year: 2020 Document type: Article Country of publication: Germany