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Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies.
Sarkar, Biplab; Siddiqui, Zain; Kim, Ka Kyung; Nguyen, Peter K; Reyes, Xavier; McGill, Trevor J; Kumar, Vivek A.
Affiliation
  • Sarkar B; Department of Biomedical Engineering, New Jersey Institute of Technology, 138 Warren St. LSEB 316, Newark, NJ, 07102, USA.
  • Siddiqui Z; Department of Biomedical Engineering, New Jersey Institute of Technology, 138 Warren St. LSEB 316, Newark, NJ, 07102, USA.
  • Kim KK; Department of Biomedical Engineering, New Jersey Institute of Technology, 138 Warren St. LSEB 316, Newark, NJ, 07102, USA.
  • Nguyen PK; Department of Biomedical Engineering, New Jersey Institute of Technology, 138 Warren St. LSEB 316, Newark, NJ, 07102, USA.
  • Reyes X; Department of Biomedical Engineering, New Jersey Institute of Technology, 138 Warren St. LSEB 316, Newark, NJ, 07102, USA.
  • McGill TJ; Casey Eye Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
  • Kumar VA; Department of Biomedical Engineering, New Jersey Institute of Technology, 138 Warren St. LSEB 316, Newark, NJ, 07102, USA. vak@njit.edu.
Drug Deliv Transl Res ; 10(5): 1191-1202, 2020 10.
Article in En | MEDLINE | ID: mdl-32232681
ABSTRACT
The retinal physiology can accrue oxidative damage and inflammatory insults due to age and metabolic irregularities. Two notable diseases that involve retinal and choroidal neovascularization are proliferative diabetic retinopathy and wet age-related macular degeneration. Currently, these diseases are mainly treated with anti-VEGF drugs (VEGF = vascular endothelial growth factor), generally on a monthly dosage scheme. We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce frequency of dosage and propose a path forward for improving patient outcomes. Graphical abstract Development of materials for long-term intravitreal delivery for management of posterior segment diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neovascularization / Choroidal Neovascularization / Diabetic Retinopathy / Wet Macular Degeneration Limits: Humans Language: En Journal: Drug Deliv Transl Res Year: 2020 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neovascularization / Choroidal Neovascularization / Diabetic Retinopathy / Wet Macular Degeneration Limits: Humans Language: En Journal: Drug Deliv Transl Res Year: 2020 Document type: Article Affiliation country: United States