Feasibility of markerless fluoroscopic real-time tumor detection for adaptive radiotherapy: development and end-to-end testing.
Phys Med Biol
; 65(11): 115002, 2020 06 05.
Article
in En
| MEDLINE
| ID: mdl-32235075
ABSTRACT
Respiratory-gated radiotherapy treatments of lung tumors reduce the irradiated normal tissue volume and potentially lower the risk of side effects. However, in clinical routine, the gating signal is usually derived from external markers or other surrogate signals and may not always correlate well with the actual tumor position. This study uses the kV-imaging system of a LINAC in combination with a multiple template matching algorithm for markerless real-time detection of the tumor position in a dynamic anthropomorphic porcine lung phantom. The tumor was realized by a small container filled with polymer dosimetry gel, the so-called gel tumor. A full end-to-end test for a gated treatment was performed and the geometric and dosimetric accuracy was validated. The accuracy of the tumor detection algorithm in SI- direction was found to be [Formula see text] mm and the gel tumor was automatically detected in 98 out of 100 images. The measured 3D dose distribution showed a uniform coverage of the gel tumor and comparison with the treatment plan revealed a high 3D [Formula see text]-passing rate of [Formula see text] ([Formula see text]). The simulated treatment confirmed the employed margin sizes for residual motion within the gating window and serves as an end-to-end test for a gated treatment based on a markerless fluoroscopic real-time tumor detection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiotherapy Planning, Computer-Assisted
/
Fluoroscopy
/
Lung Neoplasms
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Phys Med Biol
Year:
2020
Document type:
Article
Affiliation country:
Germany