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2019 ASCCP Risk-Based Management Consensus Guidelines: Methods for Risk Estimation, Recommended Management, and Validation.
Cheung, Li C; Egemen, Didem; Chen, Xiaojian; Katki, Hormuzd A; Demarco, Maria; Wiser, Amy L; Perkins, Rebecca B; Guido, Richard S; Wentzensen, Nicolas; Schiffman, Mark.
Affiliation
  • Cheung LC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
  • Egemen D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
  • Chen X; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
  • Katki HA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
  • Demarco M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
  • Wiser AL; Department of Family Medicine, Oregon Health & Science University, Portland, OR.
  • Perkins RB; Boston University School of Medicine, Boston, MA.
  • Guido RS; University of Pittsburgh/Magee-Women's Hospital, Pittsburgh, PA, USA.
  • Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
  • Schiffman M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
J Low Genit Tract Dis ; 24(2): 90-101, 2020 Apr.
Article in En | MEDLINE | ID: mdl-32243306
OBJECTIVE: To manage cervical screening abnormalities, the 2019 ASCCP management consensus guidelines will recommend clinical action on the basis of risk of cervical precancer and cancer. This article details the methods used to estimate risk, to determine the risk-based management, and to validate that the risk-based recommendations are of general use in different settings. METHODS: Based on 1.5 million patients undergoing triennial cervical screening by cotesting at the Kaiser Permanente Northern California from 2003 to 2017, we estimated risk profiles for different clinical scenarios and combinations of past and current human papillomavirus and cytology test results. We validated the recommended management by comparing with the estimated risks in several external data sources. RESULTS: Risk and management tables are presented separately by Egemen et al. and Demarco et al. Risk-based management derived from the Kaiser Permanente Northern California largely agreed with the management implied from the estimated risks of the other data sources. CONCLUSIONS: The new risk-based guidelines present management of abnormal cervical screening results. By describing the steps used to develop these guidelines, the methods presented in this article can provide a basis for future extensions of the risk-based guidelines.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Risk Management / Uterine Cervical Neoplasms Type of study: Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies / Screening_studies Limits: Female / Humans Country/Region as subject: America do norte Language: En Journal: J Low Genit Tract Dis Journal subject: GINECOLOGIA Year: 2020 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Risk Management / Uterine Cervical Neoplasms Type of study: Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies / Screening_studies Limits: Female / Humans Country/Region as subject: America do norte Language: En Journal: J Low Genit Tract Dis Journal subject: GINECOLOGIA Year: 2020 Document type: Article Country of publication: United States