Value of digital mammography in predicting lymphovascular invasion of breast cancer.
BMC Cancer
; 20(1): 274, 2020 Apr 03.
Article
in En
| MEDLINE
| ID: mdl-32245448
ABSTRACT
BACKGROUND:
Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.METHODS:
Overall 122 cases of invasive ductal carcinoma diagnosed between May 2017 and September 2018 were enrolled and assigned into the LVI positive group (n = 42) and the LVI negative group (n = 80). Independent t-test and χ2 test were performed.RESULTS:
Difference in Ki-67 between the two groups was statistically significant (P = 0.012). Differences in interstitial edema (P = 0.013) and skin thickening (P = 0.000) were statistically significant between the two groups. Multiple factor analysis showed that there were three independent risk factors for LVI interstitial edema (odds ratio [OR] = 12.610; 95% confidence interval [CI] 1.061-149.922; P = 0.045), blurring of subcutaneous fat (OR = 0.081; 95% CI 0.012-0.645; P = 0.017) and skin thickening (OR = 9.041; 95% CI 2.553-32.022; P = 0.001).CONCLUSIONS:
Interstitial edema, blurring of subcutaneous fat, and skin thickening are independent risk factors for LVI. The specificity of LVI prediction is as high as 98.8% when the three are used together.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Mammography
/
Biomarkers, Tumor
/
Ki-67 Antigen
/
Lymph Nodes
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
BMC Cancer
Journal subject:
NEOPLASIAS
Year:
2020
Document type:
Article
Affiliation country:
China