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Pyrazinamide triggers degradation of its target aspartate decarboxylase.
Gopal, Pooja; Sarathy, Jickky Palmae; Yee, Michelle; Ragunathan, Priya; Shin, Joon; Bhushan, Shashi; Zhu, Junhao; Akopian, Tatos; Kandror, Olga; Lim, Teck Kwang; Gengenbacher, Martin; Lin, Qingsong; Rubin, Eric J; Grüber, Gerhard; Dick, Thomas.
Affiliation
  • Gopal P; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Sarathy JP; MSD Translational Medicine Research Centre, Merck Research Laboratories, Singapore, Singapore.
  • Yee M; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ragunathan P; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Shin J; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Bhushan S; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Zhu J; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Akopian T; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Kandror O; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Lim TK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Gengenbacher M; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
  • Lin Q; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
  • Rubin EJ; Department of Medical Sciences, Hackensack Meridian Medical School at Seton Hall University, Nutley, NJ, USA.
  • Grüber G; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
  • Dick T; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Nat Commun ; 11(1): 1661, 2020 04 03.
Article in En | MEDLINE | ID: mdl-32245967
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazinamide / Carboxy-Lyases / Proteolysis / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Singapore
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazinamide / Carboxy-Lyases / Proteolysis / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Singapore