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Differential gene expression profile of Shigella dysenteriae causing bacteremia in an immunocompromised individual.
Muthuirulandi Sethuvel, Dhiviya Prabaa; Devanga Ragupathi, Naveen Kumar; Ninan, Marilyn M; Michael, Joy Sarojini; Anandan, Shalini; Veeraraghavan, Balaji.
Affiliation
  • Muthuirulandi Sethuvel DP; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
  • Devanga Ragupathi NK; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
  • Ninan MM; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
  • Michael JS; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
  • Anandan S; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
  • Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.
Future Sci OA ; 6(4): FSO456, 2020 Jan 29.
Article in En | MEDLINE | ID: mdl-32257369
AIM: Shigella species has varying levels of virulence gene expression with respect to different sites of infection. In this study, the differential gene expression of S. dysenteriae in response to its site of infection was analyzed by transcriptomics. METHODS: This study includes four clinical Shigella isolates. Transcriptomics was done for the stool and blood samples of a single patient. Isolates were screened for the presence of antimicrobial resistance genes. RESULTS: The majority of genes involved in invasion were highly expressed in the strain isolated from the primary site of infection. Additionally, antimicrobial resistance (dhfr1A, sulII, bla OXA. bla CTX-M-1 and qnrS) genes were identified. CONCLUSION: This study provides a concise view of the transcriptional expression of clinical strains and provides a basis for future functional studies on Shigella spp.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Future Sci OA Year: 2020 Document type: Article Affiliation country: India Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Future Sci OA Year: 2020 Document type: Article Affiliation country: India Country of publication: United kingdom