Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death.
Toxicol Res
; 36(2): 123-130, 2020 Apr.
Article
in En
| MEDLINE
| ID: mdl-32257924
ABSTRACT
Lung cancer is the most common cause of cancer-associated death worldwide. Most patients with non-small cell lung cancer die within several years of the initial diagnosis, and new therapies are desperately needed. Transmembrane protein (TMEM) 39AS41, a synthetic peptide, was generated from the protein kinase B substrate motif 34GLRNRNGSAIGLPVP48 found in the human TMEM39A protein. Myristic acid was conjugated to the N-terminus of the peptide to confer cell permeability. In this study, we found that in vitro TMEM39AS41 peptide led to cell death via inhibition of inflammation/autophagy pathways in KRAS-mutated cell and tissues. In addition, TMEM39A, at a dose of 30 mg/kg, significantly suppressed tumor growth in KRASLA1 non-small cell lung cancer mice. These results suggest that the TMEM39AS41 peptide could have therapeutic potential for lung cancer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Etiology_studies
Language:
En
Journal:
Toxicol Res
Year:
2020
Document type:
Article
Publication country:
SG
/
SINGAPORE
/
SINGAPUR
/
SINGAPURA