Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.

Zhou, Yi; Liu, Xiaoting; Xue, Junxin; Liu, Lulu; Liang, Tao; Li, Wen; Yang, Xinying; Hou, Xuben; Fang, Hao

Zhou, Yi; Liu, Xiaoting; Xue, Junxin; Liu, Lulu; Liang, Tao; Li, Wen; Yang, Xinying; Hou, Xuben; Fang, Hao.

Affiliation

Zhou Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Liu X; Department of Pharmaceutical Analysis, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Xue J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Liu L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Liang T; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Li W; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Yang X; Department of Pharmaceutical Analysis, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Hou X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.
Fang H; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University, Ji'nan, Shandong 250012, P.R. China.

J Med Chem ; 63(9): 4701-4715, 2020 05 14.

Article in En | MEDLINE | ID: mdl-32267687

Subject(s)

Antineoplastic Agents/pharmacology; Boronic Acids/pharmacology; Drug Resistance, Neoplasm/drug effects; Histone Deacetylase Inhibitors/pharmacology; Peptides/pharmacology; Proteasome Inhibitors/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/metabolism; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Boronic Acids/chemical synthesis; Boronic Acids/metabolism; Boronic Acids/toxicity; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Discovery; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints/drug effects; Histone Deacetylase 1/chemistry; Histone Deacetylase 1/metabolism; Histone Deacetylase Inhibitors/chemical synthesis; Histone Deacetylase Inhibitors/metabolism; Histone Deacetylase Inhibitors/toxicity; Humans; Molecular Docking Simulation; Multiple Myeloma/drug therapy; Peptides/chemical synthesis; Peptides/metabolism; Peptides/toxicity; Proteasome Endopeptidase Complex/chemistry; Proteasome Endopeptidase Complex/metabolism; Proteasome Inhibitors/chemical synthesis; Proteasome Inhibitors/metabolism; Proteasome Inhibitors/toxicity; Protein Binding; Protein Subunits/chemistry; Protein Subunits/metabolism; S Phase Cell Cycle Checkpoints/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Boronic Acids / Drug Resistance, Neoplasm / Histone Deacetylase Inhibitors / Proteasome Inhibitors / Antineoplastic Agents Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Country of publication: United States

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