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P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer.
Stage, Tore B; Mortensen, Christina; Khalaf, Sehbar; Steffensen, Vivien; Hammer, Helen S; Xiong, Chenling; Nielsen, Flemming; Poetz, Oliver; Svenningsen, Åsa Fex; Rodriguez-Antona, Cristina; Kroetz, Deanna L.
Affiliation
  • Stage TB; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Mortensen C; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
  • Khalaf S; Neurobiology, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
  • Steffensen V; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Hammer HS; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Xiong C; Neurobiology, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
  • Nielsen F; Signatope GmbH, Reutlingen, Germany.
  • Poetz O; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
  • Svenningsen ÅF; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Rodriguez-Antona C; Signatope GmbH, Reutlingen, Germany.
  • Kroetz DL; Neurobiology, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Clin Pharmacol Ther ; 108(3): 671-680, 2020 09.
Article in En | MEDLINE | ID: mdl-32275773
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Peripheral Nervous System Diseases / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Neurons / Antineoplastic Agents, Phytogenic Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2020 Document type: Article Affiliation country: Denmark
Fulltext
Add to My VHL
Print
XML
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / Peripheral Nervous System Diseases / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Neurons / Antineoplastic Agents, Phytogenic Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2020 Document type: Article Affiliation country: Denmark