The safety and pharmacokinetics of a novel, selective S1P1R modulator in healthy participants.

Singhal, Shalabh; Girgis, Ihab G; Xie, Jenny; Dutta, Santanu; Shevell, Diane E; Throup, John

Singhal, Shalabh; Girgis, Ihab G; Xie, Jenny; Dutta, Santanu; Shevell, Diane E; Throup, John.

Affiliation

Singhal S; Immunology and Fibrosis, Bristol Myers Squibb, Princeton, NJ, USA.
Girgis IG; Research and Animal Development, Bristol MyersSquibb, Princeton, NJ, USA.
Xie J; Discovery Biology, Bristol MyersSquibb, Princeton, NJ, USA.
Dutta S; Global Biostatistics, Bristol MyersSquibb, Princeton, NJ, USA.
Shevell DE; Precision Medicine and Companion Diagnostics, Bristol MyersSquibb, Princeton, NJ, USA.
Throup J; Immunology and Fibrosis, Bristol MyersSquibb, Princeton, NJ, USA.

Expert Opin Investig Drugs ; 29(4): 411-422, 2020 Apr.

Article in En | MEDLINE | ID: mdl-32306792

Subject(s)

Sphingosine-1-Phosphate Receptors; Tetrahydronaphthalenes/administration & dosage; Adult; Dietary Fats/administration & dosage; Double-Blind Method; Famotidine/administration & dosage; Fasting/metabolism; Healthy Volunteers; Heart Rate/drug effects; Humans; Lymphocyte Count; Middle Aged; Tetrahydronaphthalenes/adverse effects; Tetrahydronaphthalenes/pharmacokinetics; Young Adult

Key words

Absolute lymphocyte count; BMS-986166; pharmacodynamics; S1P1R; pharmacokinetics; safety

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrahydronaphthalenes / Sphingosine-1-Phosphate Receptors Type of study: Clinical_trials Limits: Adult / Humans / Middle aged Language: En Journal: Expert Opin Investig Drugs Journal subject: TERAPIA POR MEDICAMENTOS Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom

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