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A rapid and sensitive bioanalytical LC-MS/MS method for the quantitation of a novel CDK5 inhibitor 20-223 (CP668863) in plasma: Application to in vitro metabolism and plasma protein-binding studies.
Bala, Veenu; Chhonker, Yashpal S; Sleightholm, Richard L; Crawford, Ayrianne J; Hollingsworth, Michael A; Murry, Daryl J.
Affiliation
  • Bala V; Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, USA.
  • Chhonker YS; Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, India.
  • Sleightholm RL; Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, USA.
  • Crawford AJ; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • Hollingsworth MA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
  • Murry DJ; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
Biomed Chromatogr ; 34(8): e4859, 2020 Aug.
Article in En | MEDLINE | ID: mdl-32307720
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatography, Liquid / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 5 / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Biomed Chromatogr Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatography, Liquid / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 5 / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Biomed Chromatogr Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom