The role of SUMOylation during development.
Biochem Soc Trans
; 48(2): 463-478, 2020 04 29.
Article
in En
| MEDLINE
| ID: mdl-32311032
ABSTRACT
During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a 'molecular glue' by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Developmental
/
Small Ubiquitin-Related Modifier Proteins
/
Sumoylation
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Soc Trans
Year:
2020
Document type:
Article
Affiliation country:
Spain