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Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study.
Hu, Fanlei; Jiang, Xiang; Guo, Chunqing; Li, Yingni; Chen, Shixian; Zhang, Wei; Du, Yan; Wang, Ping; Zheng, Xi; Fang, Xiangyu; Li, Xin; Song, Jing; Xie, Yang; Huang, Fei; Xue, Jimeng; Bai, Mingxin; Jia, Yuan; Liu, Xu; Ren, Limin; Zhang, Xiaoying; Guo, Jianping; Pan, Hudan; Su, Yin; Yi, Huanfa; Ye, Hua; Zuo, Daming; Li, Juan; Wu, Huaxiang; Wang, Yongfu; Li, Ru; Liu, Liang; Wang, Xiang-Yang; Li, Zhanguo.
Affiliation
  • Hu F; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China. fanleihu@bjmu.edu.cn.
  • Jiang X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China. fanleihu@bjmu.edu.cn.
  • Guo C; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Li Y; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
  • Chen S; Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, USA.
  • Zhang W; Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, USA.
  • Du Y; Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, USA.
  • Wang P; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Zheng X; Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • Fang X; Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li X; Department of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity, Baotou, China.
  • Song J; Department of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Xie Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Huang F; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Xue J; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
  • Bai M; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Jia Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Liu X; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
  • Ren L; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Zhang X; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
  • Guo J; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Pan H; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Su Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Yi H; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Ye H; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Zuo D; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Li J; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Wu H; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Wang Y; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Li R; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
  • Liu L; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
  • Wang XY; Department of Human & Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, USA.
  • Li Z; Central laboratory of Eastern Division, The First Hospital of Jilin University, Changchun, China.
Nat Commun ; 11(1): 1911, 2020 04 20.
Article in En | MEDLINE | ID: mdl-32312978
Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Biomarkers / Scavenger Receptors, Class A Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Biomarkers / Scavenger Receptors, Class A Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: China Country of publication: United kingdom