Mitochondrial Protection by PARP Inhibition.

Gallyas, Ferenc; Sumegi, Balazs

Gallyas, Ferenc; Sumegi, Balazs.

Affiliation

Gallyas F; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Sumegi B; Szentagothai Research Centre, University of Pecs, 7624 Pecs, Hungary.

Int J Mol Sci ; 21(8)2020 Apr 16.

Article in En | MEDLINE | ID: mdl-32316192

Subject(s)

Mitochondria/metabolism; Poly (ADP-Ribose) Polymerase-1/metabolism; Humans; Neoplasms/drug therapy; Oxidative Stress/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Proto-Oncogene Proteins c-akt/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects

Key words

AIF; Akt; MAPK; ROS; apoptosis; cell death; mPT

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poly (ADP-Ribose) Polymerase-1 / Mitochondria Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Affiliation country: Hungary Country of publication: Switzerland

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