S-Nitroso-N-Pivaloyl-D-Penicillamine, a novel non-neuronal ACh system activator, modulates cardiac diastolic function to increase cardiac performance under pathophysiological conditions.

Oikawa, Shino; Kai, Yuko; Mano, Asuka; Nakamura, Shigeo; Kakinuma, Yoshihiko

Oikawa, Shino; Kai, Yuko; Mano, Asuka; Nakamura, Shigeo; Kakinuma, Yoshihiko.

Affiliation

Oikawa S; Department of Bioregulatory Science (Physiology), Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.
Kai Y; Department of Bioregulatory Science (Physiology), Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.
Mano A; Department of Bioregulatory Science (Physiology), Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.
Nakamura S; Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-0023, Japan.
Kakinuma Y; Department of Bioregulatory Science (Physiology), Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. Electronic address: k12417853@nms.ac.jp.

Int Immunopharmacol ; 84: 106459, 2020 Jul.

Article in En | MEDLINE | ID: mdl-32325404

Subject(s)

Cardiovascular Diseases/drug therapy; Cardiovascular Diseases/physiopathology; Heart/drug effects; Nitric Oxide Donors/pharmacology; Non-Neuronal Cholinergic System/physiology; Penicillamine/pharmacology; Ventricular Function, Left/drug effects; Animals; Blood Pressure/drug effects; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Inbred Strains; Nitric Oxide Donors/administration & dosage; Nitric Oxide Donors/therapeutic use; Penicillamine/administration & dosage; Penicillamine/analogs & derivatives; Penicillamine/therapeutic use

Key words

Acetylcholine (ACh); Cardiac diastolic function; Db/db mice; The non-neuronal ACh system in the heart; The non-neuronal cardiac cholinergic system (NNCCS)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillamine / Cardiovascular Diseases / Ventricular Function, Left / Nitric Oxide Donors / Non-Neuronal Cholinergic System / Heart Limits: Animals Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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