The functional link between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the onset of inflammation.
Pharmacol Res
; 157: 104807, 2020 07.
Article
in En
| MEDLINE
| ID: mdl-32330552
ABSTRACT
Many years have elapsed since the discovery of anti-inflammatories as effective therapeutics for the treatment of inflammatory-related diseases, but we are still uncovering their various mechanisms of action. Recent biochemical and pharmacological studies have shown that in different tissues and cell types lipid mediators from thearachidonic acid cascade, play a crucial role in the initiation and resolution of inflammation by shifting from pro-inflammatory prostaglandin (PG)E2 to anti-inflammatory PGD2 and PGJ2. Considering that until now very little is known about the biological effects evoked by microsomal prostaglandin E synthase-1 (mPGES-1) and contextually by peroxisome proliferator-activated receptor γ (PPARγ) modulation (key enzymes involved in PGE2 and PGD2/PGJ2metabolism), in this opinion paper we sought to define the coordinate functional regulation between these two enzymes at the "crossroads of phlogistic pathway" involved in the induction and resolution of inflammation.
Key words
12-HETE, (CID:5283154); 13-HODE, (CID:6443013); 13-oxoODE, (CID:6446027); 15-HETE, (CID:5280724); 5-HETE, (CID:5353349); 8-HETE, (CID:5283154); 9-HODE, (CID:5282945); 9-oxoODE, (CID:9839084); Arachidonic acid (CID:444899); Inflammation; LTB4, (CID:5280492); LTC4, (CID:5280493); LTE4, (CID:5280879); PGD(2), (CID:448457); PGE(2); PGE(2), (CID:5280360); PGF(2α), (CID:5280363); PGI(2), (CID:5282411); PPARγ; TXA(2), (CID:5280497); mPGES-1
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Inflammation Mediators
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PPAR gamma
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Prostaglandin-E Synthases
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Inflammation
Limits:
Animals
/
Humans
Language:
En
Journal:
Pharmacol Res
Journal subject:
FARMACOLOGIA
Year:
2020
Document type:
Article
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS