Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study.
J Clin Endocrinol Metab
; 105(7)2020 07 01.
Article
in En
| MEDLINE
| ID: mdl-32333763
ABSTRACT
CONTEXT Endocannabinoids are suggested to play a role in energy balance regulation. OBJECTIVE:
We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes. DESIGN ANDPARTICIPANTS:
Participants (nâ =â 38) were individually fed in energy balance with a medium protein (MP 155530% of energy from proteincarbohydratefat) or high-protein diet (HP 254530% energy from PCF) for 48 hours in a respiration chamber. MAIN OUTCOMEMEASURES:
Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed.RESULTS:
Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to body mass index (AEA) or body fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. Area under the curve (AUC) of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body fat% (Pâ <â .05).The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs the MP group.CONCLUSIONS:
In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, whereas the endocannabinoid AEA and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure during the day.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnenolone
/
Oleic Acids
/
Arachidonic Acids
/
Adipose Tissue
/
Endocannabinoids
/
Aldehydes
/
Energy Metabolism
/
Polyunsaturated Alkamides
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2020
Document type:
Article
Affiliation country:
Netherlands