Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation.

Chao, Hann-Hsiang; Karagounis, Ilias V; Thomas, Christoforos; François, Noëlle B; Facciabene, Andrea; Koumenis, Constantinos; Maity, Amit

Chao, Hann-Hsiang; Karagounis, Ilias V; Thomas, Christoforos; François, Noëlle B; Facciabene, Andrea; Koumenis, Constantinos; Maity, Amit.

Affiliation

Chao HH; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Karagounis IV; Department of Radiation Oncology, McGuire VA Medical Center, Richmond, VA, USA.
Thomas C; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
François NB; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Facciabene A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Koumenis C; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Maity A; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.

Oncogene ; 39(22): 4344-4357, 2020 05.

Article in En | MEDLINE | ID: mdl-32335582

Subject(s)

Cell Nucleus/drug effects; Cell Nucleus/radiation effects; Checkpoint Kinase 1/antagonists & inhibitors; Checkpoint Kinase 2/antagonists & inhibitors; G2 Phase Cell Cycle Checkpoints/drug effects; G2 Phase Cell Cycle Checkpoints/radiation effects; Melanoma, Experimental/immunology; Neoplasm Proteins/antagonists & inhibitors; Thiophenes/pharmacology; Urea/analogs & derivatives; Animals; Cell Line, Tumor; Female; Humans; Interferon-beta/biosynthesis; Interferon-beta/genetics; Melanoma, Experimental/drug therapy; Melanoma, Experimental/pathology; Melanoma, Experimental/radiotherapy; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Mice, Inbred C57BL; Micronucleus Tests; Neoplasm Proteins/biosynthesis; Neoplasm Proteins/genetics; RNA Interference; RNA, Small Interfering/genetics; RNA, Small Interfering/pharmacology; STAT1 Transcription Factor/biosynthesis; STAT1 Transcription Factor/genetics; Tumor Burden/drug effects; Tumor Burden/radiation effects; Urea/pharmacology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Urea / Melanoma, Experimental / Cell Nucleus / G2 Phase Cell Cycle Checkpoints / Checkpoint Kinase 2 / Checkpoint Kinase 1 / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom

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