Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks.
Dalton Trans
; 49(20): 6557-6560, 2020 May 26.
Article
in En
| MEDLINE
| ID: mdl-32342084
ABSTRACT
Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(ii) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organoplatinum Compounds
/
Phenanthridines
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Dalton Trans
Journal subject:
QUIMICA
Year:
2020
Document type:
Article
Affiliation country:
Canada