Your browser doesn't support javascript.
loading
Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks.
Lozada, Issiah B; Huang, Bin; Stilgenbauer, Morgan; Beach, Travis; Qiu, Zihan; Zheng, Yaorong; Herbert, David E.
Affiliation
  • Lozada IB; Department of Chemistry and the Manitoba Institute for Materials, University of Manitoba, 144 Dysart Road, Winnipeg, Manitoba R3T 2N2, Canada.
  • Huang B; Department of Chemistry and the Manitoba Institute for Materials, University of Manitoba, 144 Dysart Road, Winnipeg, Manitoba R3T 2N2, Canada.
  • Stilgenbauer M; Department of Chemistry, Kent State University, Kent, Ohio 44240, USA. david.herbert@umanitoba.ca.
  • Beach T; Department of Chemistry, Kent State University, Kent, Ohio 44240, USA. david.herbert@umanitoba.ca.
  • Qiu Z; Department of Chemistry, Kent State University, Kent, Ohio 44240, USA. david.herbert@umanitoba.ca.
  • Zheng Y; Department of Chemistry, Kent State University, Kent, Ohio 44240, USA. david.herbert@umanitoba.ca.
  • Herbert DE; Department of Chemistry and the Manitoba Institute for Materials, University of Manitoba, 144 Dysart Road, Winnipeg, Manitoba R3T 2N2, Canada.
Dalton Trans ; 49(20): 6557-6560, 2020 May 26.
Article in En | MEDLINE | ID: mdl-32342084
ABSTRACT
Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(ii) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Phenanthridines / Antineoplastic Agents Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Phenanthridines / Antineoplastic Agents Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Canada