Genetic Variation in Caenorhabditis elegans Responses to Pathogenic Microbiota.
Microorganisms
; 8(4)2020 Apr 24.
Article
in En
| MEDLINE
| ID: mdl-32344661
ABSTRACT
The bacterivorous nematode Caenorhabditis elegans is an important model species for understanding genetic variation of complex traits. So far, most studies involve axenic laboratory settings using Escherichia coli as the sole bacterial species. Over the past decade, however, investigations into the genetic variation of responses to pathogenic microbiota have increasingly received attention. Quantitative genetic analyses have revealed detailed insight into loci, genetic variants, and pathways in C. elegans underlying interactions with bacteria, microsporidia, and viruses. As various quantitative genetic platforms and resources like C. elegans Natural Diversity Resource (CeNDR) and Worm Quantitative Trait Loci (WormQTL) have been developed, we anticipate that expanding C. elegans research along the lines of genetic variation will be a treasure trove for opening up new insights into genetic pathways and gene functionality of microbiota interactions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Microorganisms
Year:
2020
Document type:
Article
Affiliation country:
Netherlands
Publication country:
CH
/
SUIZA
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SUÍÇA
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SWITZERLAND