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Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.
Ghosh, Arun K; Kovela, Satish; Osswald, Heather L; Amano, Masayuki; Aoki, Manabu; Agniswamy, Johnson; Wang, Yuan-Fang; Weber, Irene T; Mitsuya, Hiroaki.
Affiliation
  • Ghosh AK; Department of Chemistry, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
  • Kovela S; Department of Chemistry, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
  • Osswald HL; Department of Chemistry, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
  • Amano M; Departments of Infectious Diseases and Hematology, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto 860-8556, Japan.
  • Aoki M; Department of Medical Technology, Kumamoto Health Science University, Kumamoto 861-5598, Japan.
  • Agniswamy J; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Wang YF; Department of Clinical Sciences, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
  • Weber IT; Department of Biology, Georgia State University, Atlanta, Georgia 30303, United States.
  • Mitsuya H; Department of Biology, Georgia State University, Atlanta, Georgia 30303, United States.
J Med Chem ; 63(9): 4867-4879, 2020 05 14.
Article in En | MEDLINE | ID: mdl-32348139

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heterocyclic Compounds, Bridged-Ring / HIV-1 / HIV Protease Inhibitors / Furans Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heterocyclic Compounds, Bridged-Ring / HIV-1 / HIV Protease Inhibitors / Furans Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: United States