Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.
Sci Immunol
; 5(47)2020 05 01.
Article
in En
| MEDLINE
| ID: mdl-32358172
ABSTRACT
Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of Tregs in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by "classical" suppressive mechanisms of Tregs and by "nonclassical" reparative Treg functions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Wound Healing
/
T-Lymphocytes, Regulatory
/
Immune Tolerance
Limits:
Animals
/
Humans
Language:
En
Journal:
Sci Immunol
Year:
2020
Document type:
Article
Affiliation country:
United States