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Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer.
Jiang, Zhengyu; White, Ruth A; Wang, Timothy C.
Affiliation
  • Jiang Z; Division of Digestive and Liver Disease, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • White RA; Division of Hematology and Oncology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Wang TC; Division of Digestive and Liver Disease, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: tcw21@cumc.columbia.edu.
Trends Mol Med ; 26(8): 758-767, 2020 08.
Article in En | MEDLINE | ID: mdl-32362534
ABSTRACT
The bulk of the pancreas primarily comprises long-lived acinar cells that are not considered a bona fide source for stem cells. However, certain acinar subpopulations have a repopulating capacity during regeneration, raising the hypothesis as to the presence of regenerative progenitor-like populations in the adult pancreas. Here, we describe recent discoveries based on fate-mapping techniques that support the existence of progenitor-like acinar subpopulations, including active progenitor-like cells that maintain tissue homeostasis and facultative progenitor-like cells that drive tissue regeneration. A possible link between progenitor-like acinar cells and cancer initiators is proposed. Further analysis of these cellular components is needed, because it would help uncover possible cellular sources for regeneration and cancer, as well as potential targets for therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regeneration / Stem Cells / Pancreas, Exocrine / Acinar Cells / Neoplasms Limits: Animals / Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regeneration / Stem Cells / Pancreas, Exocrine / Acinar Cells / Neoplasms Limits: Animals / Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: United States