Targeting of Phospholipase D1 Ameliorates Collagen-Induced Arthritis via Modulation of Treg and Th17 Cell Imbalance and Suppression of Osteoclastogenesis.

Yoo, Hyun Jung; Hwang, Won Chan; Min, Do Sik

Yoo, Hyun Jung; Hwang, Won Chan; Min, Do Sik.

Affiliation

Yoo HJ; Department of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Korea.
Hwang WC; Department of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Korea.
Min DS; College of Pharmacy, Yonsei University, Incheon 21983, Korea.

Int J Mol Sci ; 21(9)2020 May 02.

Article in En | MEDLINE | ID: mdl-32370217

Subject(s)

Arthritis, Experimental/prevention & control; Benzimidazoles/pharmacology; Osteogenesis/drug effects; Phospholipase D/antagonists & inhibitors; Piperidines/pharmacology; T-Lymphocytes, Regulatory/drug effects; Th17 Cells/drug effects; Animals; Arthritis, Experimental/immunology; Arthritis, Experimental/metabolism; Arthritis, Rheumatoid/immunology; Arthritis, Rheumatoid/metabolism; Arthritis, Rheumatoid/prevention & control; Cell Differentiation/drug effects; Cell Differentiation/immunology; Cytokines/blood; Disease Models, Animal; Knee Joint/drug effects; Knee Joint/metabolism; Knee Joint/pathology; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Osteogenesis/genetics; Phospholipase D/genetics; Phospholipase D/metabolism; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism; Th17 Cells/immunology; Th17 Cells/metabolism; X-Ray Microtomography

Key words

Th17 cell; osteoclastogenesis; phospholipase D1; regulatory T cell; rheumatoid arthritis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteogenesis / Phospholipase D / Piperidines / Arthritis, Experimental / Benzimidazoles / T-Lymphocytes, Regulatory / Th17 Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Country of publication: Switzerland

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