SUMOylation in the control of cholesterol homeostasis.
Open Biol
; 10(5): 200054, 2020 05.
Article
in En
| MEDLINE
| ID: mdl-32370667
ABSTRACT
SUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis. Cholesterol is one of the main lipids required to preserve the correct cellular function, contributing to the composition of the plasma membrane and participating in transmembrane receptor signalling. Besides these functions, cholesterol is required for the synthesis of steroid hormones, bile acids, oxysterols and vitamin D. Cholesterol levels need to be tightly regulated in excess, it is toxic to the cell, and the disruption of its homeostasis is associated with various disorders like atherosclerosis and cardiovascular diseases. This review focuses on the role of SUMO in the regulation of proteins involved in the metabolism of cholesterol.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholesterol
/
Small Ubiquitin-Related Modifier Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Open Biol
Year:
2020
Document type:
Article
Affiliation country:
Spain