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Acanthopanax senticosus Root Extract Exerts Dual Action on Mouse Ileal Smooth Muscle Function, Leading to Modulation of Gastrointestinal Motility.
Miyauchi-Wakuda, Shino; Kagota, Satomi; Maruyama-Fumoto, Kana; Shiokawa, Yayoi; Yamada, Shizuo; Shinozuka, Kazumasa.
Affiliation
  • Miyauchi-Wakuda S; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University.
  • Kagota S; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University.
  • Maruyama-Fumoto K; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University.
  • Shiokawa Y; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University.
  • Yamada S; Center for Pharma-Food Research (CPFR), Graduate School of Pharmaceutical Sciences, University of Shizuoka.
  • Shinozuka K; Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University.
Biol Pharm Bull ; 43(5): 817-822, 2020.
Article in En | MEDLINE | ID: mdl-32378558
ABSTRACT
Diarrhea is often caused by changes in lifestyle, stress, or side effects of drugs. Acanthopanax senticosus root extract (ASRE) has long been used as a functional food remedy with anti-fatigue, neuroprotective, and immunomodulatory activities. However, it is unclear whether ASRE has beneficial effects on gastrointestinal (GI) motility. Therefore, we first investigated whether ASRE directly affects contractile functions of the isolated mouse ileum, and then assessed its effects on GI transit of a charcoal meal in normal mice and a carbachol (CCh)-induced diarrhea mouse model. ASRE caused contraction of the isolated mouse ileum and the maximum contraction was approximately half of that induced by acetylcholine (ACh) administration. In the presence of atropine, this ASRE-induced contraction disappeared, while relaxation responses were observed. However, ASRE reduced potassium chloride- and ACh-induced contractions, and the inhibitory effect was not counteracted by a ß-blocker. Administration of a nitric oxide synthase inhibitor or potassium channel blockers did not affect the ASRE-induced relaxation. Oral administration of ASRE for 1 and 4 d reduced the increased GI transit in CCh-treated but did not affect the GI transit of normal mice. These results indicate that ASRE exhibited dual effects of contraction via muscarinic receptors and direct relaxation on mouse ileal function, and its relaxant effect could be useful in treating diarrhea symptoms, resulting in an increase in the parasympathetic nerve activities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Eleutherococcus / Gastrointestinal Motility / Ileum / Muscle, Smooth Limits: Animals Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2020 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Eleutherococcus / Gastrointestinal Motility / Ileum / Muscle, Smooth Limits: Animals Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2020 Document type: Article