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Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
Strizhak, Alexander V; Babii, Oleg; Afonin, Sergii; Bakanovich, Iuliia; Pantelejevs, Teodors; Xu, Wenshu; Fowler, Elaine; Eapen, Rohan; Sharma, Krishna; Platonov, Maxim O; Hurmach, Vasyl V; Itzhaki, Laura; Hyvönen, Marko; Ulrich, Anne S; Spring, David R; Komarov, Igor V.
Affiliation
  • Strizhak AV; University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Spring@ch.cam.ac.uk and Enamine Ltd, Vul. Chervonotkatska 78, 02094 Kyiv, Ukraine.
  • Babii O; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany. Anne.Ulrich@kit.edu.
  • Afonin S; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany. Anne.Ulrich@kit.edu.
  • Bakanovich I; University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Spring@ch.cam.ac.uk and Enamine Ltd, Vul. Chervonotkatska 78, 02094 Kyiv, Ukraine.
  • Pantelejevs T; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
  • Xu W; University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Spring@ch.cam.ac.uk.
  • Fowler E; University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Spring@ch.cam.ac.uk.
  • Eapen R; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK.
  • Sharma K; University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Spring@ch.cam.ac.uk.
  • Platonov MO; Enamine Ltd, Vul. Chervonotkatska 78, 02094 Kyiv, Ukraine.
  • Hurmach VV; Enamine Ltd, Vul. Chervonotkatska 78, 02094 Kyiv, Ukraine and Taras Shevchenko National University of Kyiv, Vul. Volodymyrska 60, 01601 Kyiv, Ukraine.
  • Itzhaki L; Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK.
  • Hyvönen M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
  • Ulrich AS; Institute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany. Anne.Ulrich@kit.edu and Institute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
  • Spring DR; University Chemical Laboratory, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK. Spring@ch.cam.ac.uk.
  • Komarov IV; Taras Shevchenko National University of Kyiv, Vul. Volodymyrska 60, 01601 Kyiv, Ukraine and Lumobiotics GmbH, Auer Str. 2, 76227, Karlsruhe, Germany. Igor.Komarov@lumobiotics.com.
Org Biomol Chem ; 18(28): 5359-5369, 2020 07 22.
Article in En | MEDLINE | ID: mdl-32390036
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Thermodynamics / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Ethylenes Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: Ukraine Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Thermodynamics / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Ethylenes Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: Ukraine Country of publication: United kingdom