Perillyl Alcohol Mitigates Behavioural Changes and Limits Cell Death and Mitochondrial Changes in Unilateral 6-OHDA Lesion Model of Parkinson's Disease Through Alleviation of Oxidative Stress.

Anis, Ehraz; Zafeer, Mohd Faraz; Firdaus, Fakiha; Islam, Shireen Naaz; Khan, Azka Anees; Hossain, M Mobarak

Anis, Ehraz; Zafeer, Mohd Faraz; Firdaus, Fakiha; Islam, Shireen Naaz; Khan, Azka Anees; Hossain, M Mobarak.

Affiliation

Anis E; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. eanis107@myamu.ac.in.
Zafeer MF; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Firdaus F; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Islam SN; Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Khan AA; Department of Pathology, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Hossain MM; Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Neurotox Res ; 38(2): 461-477, 2020 Aug.

Article in En | MEDLINE | ID: mdl-32394056

Subject(s)

Enzyme Inhibitors/pharmacology; Mitochondria/drug effects; Monoterpenes/pharmacology; Movement/drug effects; Oxidative Stress/drug effects; Parkinsonian Disorders/metabolism; Animals; Behavior, Animal/drug effects; Caspase 3/drug effects; Caspase 3/metabolism; DNA Fragmentation/drug effects; Dynamins/drug effects; Dynamins/metabolism; Electron Transport Complex I/drug effects; Electron Transport Complex I/genetics; Electron Transport Complex I/metabolism; Electron Transport Complex IV/drug effects; Electron Transport Complex IV/genetics; Electron Transport Complex IV/metabolism; Mitochondria/metabolism; NF-E2-Related Factor 2/drug effects; NF-E2-Related Factor 2/metabolism; Oxidopamine/toxicity; Parkinsonian Disorders/physiopathology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/drug effects; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics; Proto-Oncogene Proteins c-bcl-2/drug effects; Proto-Oncogene Proteins c-bcl-2/genetics; Rats; Sympatholytics/toxicity; Tyrosine 3-Monooxygenase/drug effects; Tyrosine 3-Monooxygenase/genetics; bcl-2-Associated X Protein/drug effects; bcl-2-Associated X Protein/metabolism

Key words

6-Hydroxydopamine; Drp1; Mitochondrial dysfunction; Motor deficits; Nrf2; Oxidative stress; PGC1α; Parkinson's disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Parkinsonian Disorders / Monoterpenes / Enzyme Inhibitors / Mitochondria / Movement Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurotox Res Journal subject: NEUROLOGIA Year: 2020 Document type: Article Affiliation country: India Country of publication: United States

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