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Protective effects of Ranolazine on testicular torsion and detorsion injury in rats.
Keseroglu, Bilge Bugra; Ozer, Elif; Karakan, Tolga; Ozgur, Berat Cem; Surer, Hatice; Ogus, Elmas; Hucemenoglu, Sema; Yuceturk, Cem Nedim; Agras, Koray.
Affiliation
  • Keseroglu BB; Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Ozer E; Department of Pathology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Karakan T; Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Ozgur BC; Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Surer H; Department of Biochemistry, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Ogus E; Department of Biochemistry, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Hucemenoglu S; Department of Pathology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Yuceturk CN; Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Agras K; Department of Urology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Andrologia ; 52(7): e13616, 2020 Aug.
Article in En | MEDLINE | ID: mdl-32400086
ABSTRACT
Ranolazine is a drug used in refractory chronic stable angina. In this study, it was aimed to evaluate the protective effect of ranolazine in a testis torsion model in light of objective biochemical and pathological data. A total of 24 pre-pubertal male Wistar albino rats were separated into three groups of 8 as the sham group, control group and ranolazine group. Testis torsion was applied for 3 hr to all the rats in Group Control and Group Ranolazine. In Group Control, 0.9% NaCl was applied 1 hr after the torsion. In Group Ranolazine, ranolazine 30 mg/kg was dissolved in a 0.9% NaCl solution and was administered intraperitoneally 1 hr after torsion. Histopathological evaluation was made using the Cosentino score. As a result of the objective biochemical and pathological criteria used in this study, this protective effect of ranolazine was observed in testis torsion. The results obtained in this study may suggest that ranolazine is a drug that could be applied after detorsion to patients diagnosed with torsion.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatic Cord Torsion / Reperfusion Injury Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Andrologia Year: 2020 Document type: Article Affiliation country: Turkey

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermatic Cord Torsion / Reperfusion Injury Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Andrologia Year: 2020 Document type: Article Affiliation country: Turkey