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Biocompatibility and Therapeutic Effect of 3 Intra-Tympanic Drug Delivery Vehicles in Acute Acoustic Trauma.
Park, Mina; Hwang, Yu-Jung; Noh, Tae-Soo; Woo, Shin-Wook; Park, Ji-Hoon; Park, Seung Hun; Kim, Moon Suk; Suh, Myung-Whan.
Affiliation
  • Park M; Department of Otorhinolaryngology - Head and Neck Surgery, Seoul Medical Center, Seoul, Republic of Korea.
  • Hwang YJ; Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
  • Noh TS; Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
  • Woo SW; Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
  • Park JH; Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.
  • Park SH; Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.
  • Kim MS; Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.
  • Suh MW; Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea, drmung@naver.com.
Audiol Neurootol ; 25(6): 291-296, 2020.
Article in En | MEDLINE | ID: mdl-32403103
INTRODUCTION: The aim of this study was to assess the biocompatibility of several intra-tympanic (IT) drug delivery vehicles and to compare hearing outcomes. MATERIALS AND METHODS: After acute acoustic trauma, rats were treated with IT 10 mg/mL dexamethasone phosphate (D) and divided into the following groups for drug delivery: saline + D (n = 15), hyaluronic acid (HA) + D (n = 17), and methoxy polyethylene glycol-b-polycaprolactone block copolymer (MP) + D (n = 24). RESULTS: No inflammation was found in the saline + D or HA + D groups. The duration of vehicle/drug persistence in the bulla was significantly longer for the MP + D (47.5 days) and HA + D groups (1.8 days) than for the saline + D group (<1 day). The tympanic membrane was significantly thicker in the MP + D group than in the saline + D and HA + D groups. The proportion of ears with good hearing outcome was significantly higher (63.6%) in the HA + D group than in the MP + D group. The number of hair cells in the hearing loss (HL) control group was significantly lower than in the MP + D group. DISCUSSION/CONCLUSION: HA shows great potential as a biocompatible vehicle for D delivery via the IT route, without an inflammatory reaction and with better hearing outcomes. Considering inflammation and hearing, MP may not be a good candidate for IT drug delivery.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tympanic Membrane / Dexamethasone / Evoked Potentials, Auditory, Brain Stem / Glucocorticoids / Hearing / Hearing Loss, Noise-Induced Limits: Animals Language: En Journal: Audiol Neurootol Journal subject: AUDIOLOGIA / PSICOFISIOLOGIA Year: 2020 Document type: Article Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tympanic Membrane / Dexamethasone / Evoked Potentials, Auditory, Brain Stem / Glucocorticoids / Hearing / Hearing Loss, Noise-Induced Limits: Animals Language: En Journal: Audiol Neurootol Journal subject: AUDIOLOGIA / PSICOFISIOLOGIA Year: 2020 Document type: Article Country of publication: Switzerland