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Blood glucose regulation and control of insulin and glucagon infusion using single model predictive control for type 1 diabetes mellitus.
Crecil Dias, Cifha; Kamath, Surekha; Vidyasagar, Sudha.
Affiliation
  • Crecil Dias C; Department of Instrumentation and Control, Manipal Academy of Higher Education, Manipal Institute of Technology, Manipal, India.
  • Kamath S; Department of Instrumentation and Control, Manipal Academy of Higher Education, Manipal Institute of Technology, Manipal, India. surekha.kamath@manipal.edu.
  • Vidyasagar S; Department of Medicine, Manipal Academy of Higher Education, Kasturba Medical College, Manipal, India.
IET Syst Biol ; 14(3): 133-146, 2020 06.
Article in En | MEDLINE | ID: mdl-32406378
ABSTRACT
This study elaborates on the design of artificial pancreas using model predictive control algorithm for a comprehensive physiological model such as the Sorensen model, which regulates the blood glucose and can have a longer control time in normal glycaemic region. The main objective of the proposed algorithm is to eliminate the risk of hyper and hypoglycaemia and have a precise infusion of hormones insulin and glucagon. A single model predictive controller is developed to control the bihormones, insulin, and glucagon for such a development unmeasured disturbance is considered for a random time. The simulation result for the proposed algorithm performed good regulation lowering the hypoglycaemia risk and maintaining the glucose level within the normal glycaemic range. To validate the performance of the tracking of output and setpoint, average tracking error is used and 4.4 mg/dl results are obtained while compared with standard value (14.3 mg/dl).
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Glucagon / Diabetes Mellitus, Type 1 / Insulin / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: IET Syst Biol Journal subject: BIOLOGIA / BIOTECNOLOGIA Year: 2020 Document type: Article Affiliation country: India

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Glucagon / Diabetes Mellitus, Type 1 / Insulin / Models, Biological Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: IET Syst Biol Journal subject: BIOLOGIA / BIOTECNOLOGIA Year: 2020 Document type: Article Affiliation country: India