Pharmacokinetics, Pharmacodynamics, and Exposure-Response of Lanadelumab for Hereditary Angioedema.

Wang, Yi; Marier, Jean-Francois; Kassir, Nastya; Chang, Colin; Martin, Patrick

Wang, Yi; Marier, Jean-Francois; Kassir, Nastya; Chang, Colin; Martin, Patrick.

Affiliation

Wang Y; Shire, a Takeda company, Cambridge, Massachusetts, USA.
Marier JF; Certara Strategic Consulting, Princeton, New Jersey, USA.
Kassir N; Certara Strategic Consulting, Princeton, New Jersey, USA.
Chang C; Certara Strategic Consulting, Princeton, New Jersey, USA.
Martin P; Shire, a Takeda company, Cambridge, Massachusetts, USA.

Clin Transl Sci ; 13(6): 1208-1216, 2020 11.

Article in En | MEDLINE | ID: mdl-32407574

Subject(s)

Angioedemas, Hereditary/drug therapy; Antibodies, Monoclonal, Humanized/pharmacokinetics; Plasma Kallikrein/antagonists & inhibitors; Secondary Prevention/methods; Adolescent; Adult; Aged; Angioedemas, Hereditary/blood; Antibodies, Monoclonal, Humanized/administration & dosage; Area Under Curve; Bradykinin/metabolism; Child; Datasets as Topic; Dose-Response Relationship, Drug; Drug Interactions; Female; Healthy Volunteers; Humans; Injections, Subcutaneous; Kininogens/metabolism; Male; Middle Aged; Plasma Kallikrein/metabolism; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma Kallikrein / Angioedemas, Hereditary / Secondary Prevention / Antibodies, Monoclonal, Humanized Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Language: En Journal: Clin Transl Sci Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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