The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-&#954;B-p65/TNF-&#945; Signaling Pathways.

Ali, Fares E M; Saad Eldien, Heba M; Mostafa, Nashwa A M; Almaeen, Abdulrahman H; Marzouk, Mohamed R A; Eid, Khalid M; Ghoziz, Ahmed H E; Ebrahiem, Abdelaziz F; Hagag, Mohamed G; Ghogar, Osama M

The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways.

Ali, Fares E M; Saad Eldien, Heba M; Mostafa, Nashwa A M; Almaeen, Abdulrahman H; Marzouk, Mohamed R A; Eid, Khalid M; Ghoziz, Ahmed H E; Ebrahiem, Abdelaziz F; Hagag, Mohamed G; Ghogar, Osama M.

Affiliation

Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt.
Saad Eldien HM; Department of Anatomy, College of Medicine, Jouf University, Saudi Arabia.
Mostafa NAM; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Almaeen AH; Department of Pathology, College of medicine, Jouf University, Saudi Arabia.
Marzouk MRA; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Eid KM; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ghoziz AHE; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ebrahiem AF; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Hagag MG; Pharmacy student, Faculty of Pharmacy, Al- Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ghogar OM; Pharmacy student, Faculty of Pharmacy, Al- Azhar University, Assiut Branch, Assiut, 71524, Egypt.

Curr Mol Pharmacol ; 14(1): 88-100, 2021.

Article in En | MEDLINE | ID: mdl-32410568

Subject(s)

Antioxidants/chemistry; Fatty Acids/chemistry; Ischemia/drug therapy; Reperfusion Injury/drug therapy; Animals; Antioxidants/pharmacology; Cytoglobin/genetics; Cytoglobin/metabolism; Electron Transport Complex IV/genetics; Electron Transport Complex IV/metabolism; Fatty Acids/pharmacology; Female; Heme Oxygenase-1/genetics; Heme Oxygenase-1/metabolism; Hepatocytes; Humans; Interleukin-10/metabolism; Liver; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; Oxidative Stress/drug effects; Rats, Wistar; Reperfusion; Signal Transduction; Superoxide Dismutase/metabolism; Transcription Factor RelA/genetics; Transcription Factor RelA/metabolism; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

Nrf-2/HO-1/COX-4; P38-MAPK/NF-κB-p65/TNF-α; Royal jelly; cytoglobin; hepatic IR; hepatoprotective

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury / Fatty Acids / Ischemia / Antioxidants Limits: Animals / Female / Humans Language: En Journal: Curr Mol Pharmacol Journal subject: FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: Egypt Country of publication: United Arab Emirates

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