The renin-angiotensin system - a therapeutic target in COVID-19?

Sturrock, Beattie Rh; Milne, Kate M; Chevassut, Timothy Jt

Sturrock, Beattie Rh; Milne, Kate M; Chevassut, Timothy Jt.

Affiliation

Sturrock BR; Brighton and Sussex Medical School, Brighton UK and Royal Sussex County Hospital, Brighton, UK.
Milne KM; Brighton and Sussex Medical School, Brighton UK and Royal Sussex County Hospital, Brighton, UK.
Chevassut TJ; Brighton and Sussex Medical School, Brighton UK and consultant haematologist, Royal Sussex County Hospital, Brighton, UK t.chevassut@bsms.ac.uk.

Clin Med (Lond) ; 20(4): e72-e75, 2020 07.

Article in En | MEDLINE | ID: mdl-32414711

Subject(s)

Angiotensin II/metabolism; Antihypertensive Agents/therapeutic use; Betacoronavirus/physiology; Coronavirus Infections/metabolism; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/metabolism; Renin-Angiotensin System; Amides/therapeutic use; Angiotensin Receptor Antagonists/therapeutic use; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Animals; COVID-19; Coronavirus Infections/complications; Coronavirus Infections/drug therapy; Fumarates/therapeutic use; Humans; Lung Injury/metabolism; Lung Injury/virology; Mice; Pandemics; Pneumonia, Viral/complications; Pneumonia, Viral/drug therapy; SARS-CoV-2; Virus Internalization

Key words

ACE2; COVID-19; RAS; Reninangiotensin system; lung injury

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Angiotensin II / Coronavirus Infections / Peptidyl-Dipeptidase A / Betacoronavirus / Antihypertensive Agents Limits: Animals / Humans Language: En Journal: Clin Med (Lond) Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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